Robust epidemic aggregation under churn

In large-scale distributed systems data aggregation is a fundamental task that provides a global synopsis over a distributed set of data values. Epidemic protocols are based on a randomised communication paradigm inspired by biological systems and have been proposed to provide decentralised, scalable and fault-tolerant solutions to the data aggregation problem. However, in epidemic aggregation, nodes failure and churn have a detrimental effect on the accuracy of the local estimates of the global aggregation target. In this paper, a novel approach, the Robust Epidemic Aggregation Protocol (REAP), is proposed to provide robustness in the presence of churn by detecting three distinct phases in the aggregation process. An analysis of the impact of each phase over the estimation accuracy is provided. In particular, a novel mechanism is introduced to improve the phase that is most critical for the protocol accuracy. REAP is validated by means of simulations and is shown to achieve convergence with a good level of accuracy for a reasonable range of node churn rates

Shear band dynamics from a mesoscopic modeling of plasticity

The ubiquitous appearance of regions of localized deformation (shear bands) in different kinds of disordered materials under shear is studied in the context of a mesoscopic model of plasticity. The model may or may not include relaxational (aging) effects. In the absence of relaxational effects the model displays a monotonously increasing dependence of stress on strain-rate, and stationary shear bands do not occur. However, in start up experiments transient (although long lived) shear bands occur, that widen without bound in time. I investigate this transient effect in detail, reproducing and explaining a t^1/2 law for the thickness increase of the shear band that has been obtained in atomistic numerical simulations. Relaxation produces a negative sloped region in the stress vs. strain-rate curve that stabilizes the formation of shear bands of a well defined width, which is a function of strain-rate. Simulations at very low strain-rates reveal a non-trivial stick-slip dynamics of very thin shear bands that has relevance in the study of seismic phenomena. In addition, other non-stationary processes, such as stop-and-go, or strain-rate inversion situations display a phenomenology that matches very well the results of recent experimental studies.Comment: 10 pages, 10 figure

USE OF KINECT AZURE FOR BIM RECONSTRUCTION: ESTABLISHMENT OF AN ACQUISITION PROTOCOL, SEGMENTATION AND 3D MODELING

With the popularization of RGB-D cameras, access to the third dimension is now possible at low cost. However, these systems have a lower accuracy compared to other technologies such as terrestrial laser scanners (TLS) or mobile laser scanners (MLS). RGB-D cameras have proved their potential for 3D indoor mapping, particularly for Building Information Models reconstruction (Li et al., 2020). This paper aims to investigate the acquisition protocol and propose a method for BIM reconstruction by using an RGB-D camera (Kinect Azure). First, an acquisition protocol is established with the aim of improving the quality of 3D reconstruction of indoor scenes. Different scene cases are considered, namely a single wall, a corridor, a room (with different levels of detail) and two adjacent rooms. After having extracted the best acquisition scenarios for each case of the studied scenes, an image processing is performed for the most complex scenes. Then the 3D reconstruction is performed and the resulting point clouds are subsampled and cleaned. Next, an evaluation of the geometric quality of the 3D reconstruction is performed, by making a comparison between the point clouds from the acquisition protocol (room and corridor) and the reference point clouds from an MLS. The results of this comparison shows that the differences between the two point clouds have an absolute average deviation that doesn’t exceed 4.8mm, which proves that the proposed method has reached competitive accuracy. Finally, segmentation and 3D modeling of the studied scenes are proceeded to extract the BIM objects

Monotherapy with pixantrone in histologically confirmed relapsed or refractory aggressive B-cell non-Hodgkin lymphoma: post-hoc analyses from a phase III trial.

This post hoc analysis of a phase 3 trial explored the effect of pixantrone in patients (50 pixantrone, 47 comparator) with relapsed or refractory aggressive B-cell non-Hodgkin lymphoma (NHL) confirmed by centralized histological review. Patients received 28-d cycles of 85 mg/m(2) pixantrone dimaleate (equivalent to 50 mg/m(2) in the approved formulation) on days 1, 8 and 15, or comparator. The population was subdivided according to previous rituximab use and whether they received the study treatment as 3rd or 4th line. Median number of cycles was 4 (range, 2-6) with pixantrone and 3 (2-6) with comparator. In 3rd or 4th line, pixantrone was associated with higher complete response (CR) (23·1% vs. 5·1% comparator, P = 0·047) and overall response rate (ORR, 43·6% vs. 12·8%, P = 0·005). In 3rd or 4th line with previous rituximab (20 pixantrone, 18 comparator), pixantrone produced better ORR (45·0% vs. 11·1%, P = 0·033), CR (30·0% vs. 5·6%, P = 0·093) and progression-free survival (median 5·4 vs. 2·8 months, hazard ratio 0·52, 95% confidence interval 0·26-1·04) than the comparator. Similar results were found in patients without previous rituximab. There were no unexpected safety issues. Pixantrone monotherapy is more effective than comparator in relapsed or refractory aggressive B-cell NHL in the 3rd or 4th line setting, independently of previous rituximab

Phenomenology and physical origin of shear-localization and shear-banding in complex fluids

We review and compare the phenomenological aspects and physical origin of shear-localization and shear-banding in various material types, namely emulsions, suspensions, colloids, granular materials and micellar systems. It appears that shear-banding, which must be distinguished from the simple effect of coexisting static-flowing regions in yield stress fluids, occurs in the form of a progressive evolution of the local viscosity towards two significantly different values in two adjoining regions of the fluids in which the stress takes slightly different values. This suggests that from a global point of view shear-banding in these systems has a common physical origin: two physical phenomena (for example, in colloids, destructuration due to flow and restructuration due to aging) are in competition and, depending on the flow conditions, one of them becomes dominant and makes the system evolve in a specific direction.Comment: The original publication is available at http://www.springerlink.co

GaSbBi alloys and heterostructures: fabrication and properties

International audienceDilute bismuth (Bi) III-V alloys have recently attracted great attention, due to their properties of band-gap reduction and spin-orbit splitting. The incorporation of Bi into antimonide based III-V semiconductors is very attractive for the development of new optoelectronic devices working in the mid-infrared range (2-5 µm). However, due to its large size, Bi does not readily incorporate into III-V alloys and the epitaxy of III-V dilute bismides is thus very challenging. This book chapter presents the most recent developments in the epitaxy and characterization of GaSbBi alloys and heterostructures

Hydrogen storage in liquid hydrogen carriers: recent activities and new trends

Efficient storage of hydrogen is one of the biggest challenges towards a potential hydrogen economy. Hydrogen storage in liquid carriers is an attractive alternative to compression or liquefaction at low temperatures. Liquid carriers can be stored cost-effectively and transportation and distribution can be integrated into existing infrastructures. The development of efficient liquid carriers is part of the work of the International Energy Agency Task 40: Hydrogen-Based Energy Storage. Here, we report the state-of-the-art for ammonia and closed CO2-cycle methanol-based storage options as well for liquid organic hydrogen carriers

Recent experimental probes of shear banding

Recent experimental techniques used to investigate shear banding are reviewed. After recalling the rheological signature of shear-banded flows, we summarize the various tools for measuring locally the microstructure and the velocity field under shear. Local velocity measurements using dynamic light scattering and ultrasound are emphasized. A few results are extracted from current works to illustrate open questions and directions for future research.Comment: Review paper, 23 pages, 11 figures, 204 reference

EPIdemiology of Surgery-Associated Acute Kidney Injury (EPIS-AKI) : Study protocol for a multicentre, observational trial

More than 300 million surgical procedures are performed each year. Acute kidney injury (AKI) is a common complication after major surgery and is associated with adverse short-term and long-term outcomes. However, there is a large variation in the incidence of reported AKI rates. The establishment of an accurate epidemiology of surgery-associated AKI is important for healthcare policy, quality initiatives, clinical trials, as well as for improving guidelines. The objective of the Epidemiology of Surgery-associated Acute Kidney Injury (EPIS-AKI) trial is to prospectively evaluate the epidemiology of AKI after major surgery using the latest Kidney Disease: Improving Global Outcomes (KDIGO) consensus definition of AKI. EPIS-AKI is an international prospective, observational, multicentre cohort study including 10 000 patients undergoing major surgery who are subsequently admitted to the ICU or a similar high dependency unit. The primary endpoint is the incidence of AKI within 72 hours after surgery according to the KDIGO criteria. Secondary endpoints include use of renal replacement therapy (RRT), mortality during ICU and hospital stay, length of ICU and hospital stay and major adverse kidney events (combined endpoint consisting of persistent renal dysfunction, RRT and mortality) at day 90. Further, we will evaluate preoperative and intraoperative risk factors affecting the incidence of postoperative AKI. In an add-on analysis, we will assess urinary biomarkers for early detection of AKI. EPIS-AKI has been approved by the leading Ethics Committee of the Medical Council North Rhine-Westphalia, of the Westphalian Wilhelms-University Münster and the corresponding Ethics Committee at each participating site. Results will be disseminated widely and published in peer-reviewed journals, presented at conferences and used to design further AKI-related trials. Trial registration number NCT04165369